Clinical treatment trials are studies that try to improve prevention, advance current treatment or find new treatments for diseases. They are the only reliable way to prove the effectiveness of various treatments. During a clinical trial, information is carefully collected to assess improvement in outcomes, and risks that may be associated with new treatments.
Please keep in mind that there are many different types of diseases, and the medical names can sound confusingly similar, especially for closely related diseases and for different stages of the same disease. You should discuss your diagnosis with your physician and know what your situation is before drawing any conclusions or making any decisions.
For more information, please call (803) 434-3680 or 1-800-775-2287.
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Clinical Treatment Trials with Palmetto Health Institutional Review Board approval. |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2006-128
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PH IRB #2006-128: CONNECT: Clinical Evaluation of Remote Notification to Reduce Time to Clinical Decision.
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| Disease: Acute Lymphoblastic Leukemia |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2004-41
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COG
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AALL0232
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High Risk B-precursor Acute Lymphoblastic Leukemia.
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Linda Sherriff
(803) 434-4795
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2004-42
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COG
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AALL03B1
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Classification of Acute Lymphoblastic Leukemia.
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Linda Sherriff
(803) 434-4795
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2007-82
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COG
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AALL0433
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Intensive Treatment for Intermediate-Risk Relapse of Childhood B-Precursor Acute Lymphoblastic Leukemia (ALL): A Randomized Trial of Vincristine Strategies, A Groupwide Phase III Study.
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Linda Sherriff
(803) 434-4795
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2007-76
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COG
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AALL0434
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Intensified Methotrexate, Nelarabine (Compound 506U78; IND # 52611) and Augmented BFM Therapy for Children and Young Adults with Newly Diagnosed T-cell Acute Lymphoblastic Leukemia: A Groupwide Phase III Study.
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Linda Sherriff
(803) 434-4795
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2007-09
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COG
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AALL05B1
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A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens.
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Linda Sherriff
(803) 434-4795
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| Disease: Acute Myeloid Leukemia |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2007-17
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COG
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AAML0531
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A Phase III Randomized Trial of Gemtuzumab Ozogamicin (Mylotarg) Combined with Conventional Chemotherapy for De Novo Acute Myeloid Leukemia (AML) in Children, Adolescents, and Young Adults.
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Linda Sherriff
(803) 434-4795
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| Disease: Advanced Staged Epithelial Ovarian Cancer |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2005-91
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GOG
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0218
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A Phase III Trial of Carboplatin and Paclitaxel Plus Placebo versus Carboplatin and Paclitaxel Plus Concurrent Bevacizumab followed by Placebo, Bevacizumab, in Women with Newly Diagnosed, Previously Untreated, Suboptimal Advanced Stage Epithelial Ovarian and Primary Peritoneal Cancer.
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Dr. James Williams
(803) 461-3000
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| Disease: Alzheimer's Disease |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2004-39
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South Carolina Alzheimer's Disease Research Center
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South Carolina Alzheimer's Disease Research Center Clinical Core Study (ADRC-CCS).
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Linda Sherriff
(803) 434-4439
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2005-03
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National Institute on Aging/NIH/DHHS
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A Randomized, Double-Blind, Placebo-Controlled Trial of Valproate to Attenuate the Progression of Alzheimer's Disease (AD).
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Linda Sherriff
(803) 434-4439
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| Disease: Birth Defects Prevention |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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93-88
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Centers for Disease Control and Prevention/DHHS
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South Carolina Birth Defects Prevention and Surveillance Program
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Roger E. Stevenson, M.D.
(864) 941-8100
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| Disease: Breast Cancer Markers |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2004-53
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University of South Carolina
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An Attempt to Identify Carriers of the Hereditary Breast Cancer Genes BRCA1 and BRCA2 by Using Patient Age and the Tumor Markers High Grade and Estrogen Receptor Negative.
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Robert S. Young, Ph.D.
(803) 779-4928, ext. 230
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| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2006-128
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CONNECT: Clinical Evaluation of Remote Notification to Reduce Time to Clinical Decision.
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Linda Sherriff
(803) 434-4795
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| Disease: Chest Wall and Spine Deformity Registry |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2005-41
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Vertical Expandable Prosthetic Titanium Rib (VEPTR) Usage in Children, Humanitarian Use Device, The Chest Wall and Spine Deformity Registry.
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Mark D. Locke, M.D., F.A.A.P
(803) 227-8161
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| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2007-70
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Concordance in Patient & Provider Experiences with Chronic Disease Care.
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Michael Faircloth, M.D.
Family Practice
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| Disease: Colon Polyp Prevention |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2004-19
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National Cancer Institute/NIH/DHHS
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Vitamin D/Calcium Polyp Prevention Study.
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Roberd M. Bostick, M.D., M.P.H.
(803) 767-1829
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| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2005-36
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Language and Memory in Aging Dementia - A Pilot Study.
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Linda Sherriff
(803) 434-4439
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| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2004-23
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Palmetto Health Alliance
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Pre-Diabetes Program Evaluation
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Philip J. Michels, Ph.D.
(803) 434-2425
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| Disease: Endometrial Carcinoma |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2004-04
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GOG
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0210
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A Molecular Staging Study of Endometrial Carcinoma.
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Dr. James Williams
(803) 461-3000
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| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2007-97
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COG
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AEWS0621
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Phase II Trial of Intermediate-Dose Cytarabine to Modulate EWS/FLI for Children and Young Adults with Recurrent or Refractory Ewing Sarcoma.
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Linda Sherriff
(803) 434-4795
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| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2004-08
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Physical Activity and Gastric Bypass: Optimizing Post-Surgical Care.
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Debbie Horn, D.O., M.P.H.
(803) 479-4612
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| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2007-27
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Vitamin D in South Carolina's Seniors: A Pilot Study.
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Michele Neese, R.N.
(803) 434-4439
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2007-115
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Exploring effectiveness of dynamic balance training program intervention- “Stay in Balance”- to improve fall risk in community dwelling Older adults.
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Margaret M. Matthews, M.D., Ph.D.
Geriatrics
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| Disease: Geriatrics-Exercise Counseling |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2007-03
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A Comparison of Physician Based Exercise Counseling Protocols: A Pilot Study. Does physical activity counseling provided by a physician in the form of verbal, written or combination delivery increase physical activity in a sedentary geriatric population?
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Amanda Richardson
(803) 434-4439
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| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2007-29
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The Baromedical Research Foundation
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A Phase I Clinical Trial Of Hyperbaric Oxygen Combined with Radiation and Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck.
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Lindsie Cone, M.D.
Hyperbaric Medicine
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| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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97-32
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CDC
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1671
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Universal Data and Serum Specimen Collection System for Hemophilia
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Linda Sherriff
(803) 434-4795
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| Disease: Hodgkin's Disease |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2003-57
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COG
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AHOD0031
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A Phase III Group-wide Study to Dose-Intensive Response-Based Chemotherapy and Radiation Therapy for Children and Adolescents with Newly Diagnosed Intermediate Risk Hodgkin's Disease.
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Linda Sherriff
(803) 434-4795
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2006-27
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COG
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AHOD03P1
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Treatment of Children with Newly-Diagnosed Low Stage Lymphocyte Predominant Hodgkins Disease (LPHD).
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Linda Sherriff
(803) 434-4795
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|
2006-60
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COG
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AHOD0431
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A Phase III Study for the Treatment of Children and Adolescents with Newly Diagnosed Low Risk Hodgkin Disease.
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Linda Sherriff
(803) 434-4795
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2007-10
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COG
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AHOD04B1
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Banking in Hodgkin Disease.
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Linda Sherriff
(803) 434-4795
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2007-107
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COG
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AHOD0521
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A Phase II Study of Bortezomib (Velcade, PS-341, IND # 58443) in Combination with Ifosfamide/Vinorelbine in Pediatric Patients and Young Adults with Refractory/Recurrent Hodgkin Disease.
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Linda Sherriff
(803) 434-4795
|
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2007-07
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04-MCH-343-ORC
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A Study of Decisions Surrounding Lung Cancer Surgery.
|
Linda Sherriff
(803) 434-4795
|
| Disease: Nasopharyngeal Carcinoma |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2006-92
|
COG
|
ARAR0331
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Treatment of Childhood Nasopharyngeal Carcinoma with Neoadjuvant Chemotherapy and Concomitant Chemoradiotherapy.
|
Linda Sherriff
(803) 434-4795
|
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2001-63
|
COG
|
ANBL00B1
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Neuroblastoma Biology Studies.
|
Linda Sherriff
(803) 434-4795
|
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2002-92
|
COG
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ANBL00P2
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Perinatal Neuroblastoma: Expectant Observation. A COG Pilot Study.
|
Linda Sherriff
(803) 434-4795
|
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2002-96
|
COG
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ANBL0032
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Phase III Randomized Study of Chimeric Antibody 14.18 in High Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue.
|
Linda Sherriff
(803) 434-4795
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2006-58
|
COG
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ANBL0421
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A Phase II Study of Irinotecan + Temozolomide in Chilldren with Recurrent Neuroblastoma.
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Linda Sherriff
(803) 434-4795
|
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
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2007-112
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Total Parental Nutrition: Determination of Utilization and Appropriateness among Hospitalized Adults in South Carolina's Leading Medical Centers.
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Joan Conyers
(803) 434-7880
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| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2004-72
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Canadian Institutes of Health Research
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Early External Cephalic Version 2 Trial (EEVC 2).
|
Stanette Brown
(803) 779-4928
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2005-19
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University of Toronto
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Twin Birth Study (TBS).
|
Stanette Brown
(803) 779-4928
|
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2005-58
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Saline Infusion Sonography to Determine Bilateral Tubal Occlusion in Women After Hysteroscopic Bilateral Tubaligation by Essure Microinserts.
|
Stanette Brown
(803) 779-4928
|
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2006-119
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American Medical Systems, Inc.
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Clinical Study Protocol Number 1004: A Prospective, Multi-Center Study to Assess the AMS Pelvic Floor Repair System Devices for Prolapse Repair.
|
Stanette Brown
(803) 779-4928
|
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2007-145
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Stryker Biotech
|
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OP-1 Implant (HUD).
|
Dr. Michael Tucker
Orthopedics
|
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2005-78
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|
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Effect of Undetected OSA on Post–Operative Complications Post-CABG
|
Dr. Sunil Sharma
(803) 540-1000
|
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2005-89
|
COG
|
AOST0331
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A Randomized Trial of the European and American Osteosarcoma Study Group to Optimize Treatment Strategies for Resectable Osteosarcoma based on Histological Response to Pre-Operative Chemotherapy, A Phase III Intergroup Study.
|
Linda Sherriff
(803) 434-4795
|
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2002-64
|
GOG
|
198
|
A Randomized Study of Tamoxifen versus Thalidomide in Patients with Biochemical-Recurrence-Only Epithelial Ovarian Cancer of the Fallopian Tube, and Primary Peritoneal Carcinoma After First Line Chemotherapy.
|
Dr. James Williams
(803) 461-3000
|
| Disease: Ovarian Stromal Tumors |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2001-07
|
GOG
|
187
|
Phase II Study of Paclitaxel for Ovarian Stromal Tumors as First-Line Therapy or Second-Line Therapy
|
Dr. James Williams
(803) 461-3000
|
| Disease: Pain Perception in Trauma Patients |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2005-33
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The Effect of Prior Drug Use on Analgesic Need and Perception of Pain in Trauma Patients.
|
Stephen Fann, M.D.
(803) 256-2657
|
| Disease: Pediatric Acute Lymphoblastic Leukemia |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2005-31
|
COG
|
AALL0331
|
Standard Risk B-precursor Acute Lymphoblastic Leukemia.
|
Linda Sherriff
(803) 434-4795
|
|
2005-46
|
COG
|
AALL03N1
|
Understanding the Role of Adherence in the Ethnic Differences in Survival after Childhood ALL.
|
Linda Sherriff
(803) 434-4795
|
| Disease: Pediatric Brain Tumors |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2005-10
|
COG
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ACNS02B3
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Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens.
|
Linda Sherriff
(803) 434-4795
|
|
2006-23
|
COG
|
ACNS0221
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A Phase II Study of Conformal Radiotherapy in Patients with Low-Grade Gliomas.
|
Linda Sherriff
(803) 434-4795
|
|
2007-149
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COG
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ACNS0222
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A Phase II Study of Motexafin-Gadolinium (NSC 695238, IND #55583) And Involved Field Radiation Therapy For Intrinsic Pontine Glioma of Childhood, A Groupwide Phase II Study
|
Linda Sherriff
(803) 434-4795
|
|
2007-106
|
COG
|
ACNS0232
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Radiotherapy Alone vs. Chemotherapy Followed by Response-based Radiotherapy for Newly Diagnosed Primary CNS Germinoma.
|
Linda Sherriff
(803) 434-4795
|
|
2007-81
|
COG
|
ACNS0332
|
Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients.
|
Linda Sherriff
(803) 434-4795
|
| Disease: Pediatric Low-Risk Rhabdomyosarcoma |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2005-45
|
COG
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ARST0331
|
Vincristine, Dactinomycin, and Lower Doses of Cyclophosphamide with or without Radiation Therapy for Patients with Newly Diagnosed Low-Risk Embryonal/Botryoid/Spindle Cell Rhabdomyosarcoma.
|
Linda Sherriff
(803) 434-4795
|
|
2007-15
|
COG
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ARST0531
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Randomized Study of Vincristine, Dactinomycin and Cyclophosphamide (VAC) versus VAC Alternating with Vincristine and Irinotecan (VI) for Patients with Intermediate-Risk Rhabdomyosarcoma (RMS).
|
Linda Sherriff
(803) 434-4795
|
| Disease: Pediatric Osteosarcoma |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2004-30
|
COG
|
P9851
|
Osteosarcoma Biology Protocol.
|
Linda Sherriff
(803) 434-4795
|
| Disease: Pediatric Standard Risk Medulloblastoma |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2004-44
|
COG
|
ACNS0331
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A Study Evaluating Limited Target Volume Boost Irradiation and Reduced Dose Craniospinal Radiotherapy 18.00 Gy and Chemotherapy in Children with Newly Diagnosed Standard Risk Medulloblastoma: A Phase III Double Randomized Trial.
|
Linda Sherriff
(803) 434-4795
|
| Disease: Pediatric Wilms Tumor |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
96-51
|
COG
|
4941L
|
National Wilms Tumor Late Effects Study
|
Linda Sherriff
(803) 434-4795
|
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2007-110
|
|
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The Effectiveness of Heller Myotomy as a Treatment for Achalasia in the Young Pediatric Population: evaluated by postoperative manometry.
|
Juan Camps, M.D.
(803)434-4555
|
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2007-19
|
|
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Maternal and Newborn Outcomes of Patients Attending the Management of Obesity in Pregnancy Clinic: Data Collection and Analysis for Patient Quality Improvement and Publication.
|
Stanette Brown, R.N.
(803) 779-4928, ext 252
|
| Disease: Prevention-Diet and Breast Cancer |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2000-69
|
Department of Defense
|
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Quasi-Prospective Study of Diet and Breast Cancer.
|
James R. Hebert
(803) 734-4489
|
| Disease: Prevention-Prostate Cancer |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2003-02
|
Department of Defense
|
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A Diet, Physical Activity and Meditation Intervention in Men with Rising Prostate-Specific Antigen (PSA).
|
James R. Hebert
(803) 734-4489
|
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
2004-14
|
National Institute of Mental Health/NIH/DHHS
|
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Social Support for Mothers of Mentally Ill Children.
|
Kathleen M. Scharer
(803) 777-2868
|
|
2004-62
|
National Cancer Institute/NIH/DHHS
|
|
Teleconference Group: Breast Cancer In African-Americans.
|
Sue Heiney, Ph.D.
(803) 434-4733
|
|
2004-03
|
|
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Depression and Grief following Pregnancy Loss.
|
Joshua Mann, M.D.
(803) 434-4575
|
| Disease: Pulmonary Disease |
| IRB # |
Sponsor |
Study # |
Study Title |
Contact |
|
