South Carolina Cancer Center: Research Information

2002 Annual Report

Report of the State of the South Carolina Cancer Center
for the July 2002 Directors Retreat

William M Butler MD FACP
Director of Research and Education
South Carolina Cancer Center

The following is a summary of the activities, publications, personnel, goals and future directions for the South Carolina Cancer Center. I became Director of the Cancer Center in April 2002 and have begun to gather the information necessary to understand the financial structure of the Center, refocus personnel on the goals of building a cancer research program in Columbia, and developing clinical programs that enhance quality of patient care. This summary will cover the areas of basic research, clinical research, oncology education, patient care in the cancer center, funding for the cancer center and the scope of our cancer programs.

We hope to achieve a major goal with the receipt of the COBRE grant from the NIH. This grant will greatly accelerate growth of the Cancer Center. Many new researchers will join our research programs as a result of the hard work of Dr. Frank Berger and his team of co-investigators. Drs. Creek and Pirisi also achieved major funding this year that will add new post-doctoral researchers to the SCCC and Drs. Wargovich and Xie recently obtained NIH grants.

There were many scientific publications from the SCCC this year. They are listed separately on this web page.

I have briefly listed the SCCC researchers and their areas of interest so that you can be better aware of their names and research interest. The major focus areas for research in the SCCC continue to be Breast, Prostate, Colon, and Cervical cancer.

Educational programs for patients, the public, hospital staff, residents and students are all responsibilities of the SCCC. We are becoming more active in resident and student education. This year our group was recognized for outstanding teaching by the residents in internal medicine. We will become more formally involved in resident training in July 2002. Doctors Woods and Christiansen will become co-directors for the division of hematology and oncology at the University of South Carolina School of Medicine. We will begin monthly lectures for the internal medicine residents in July and have agreed to take residents on our oncology services beginning in July 2002.

The annual Spring Breast Symposium was a great success this year with more than 200 attendees. Several visiting speakers presented data and our South Carolina Comprehensive Breast Center presented an update of the ongoing activities and research.

Our community education programs continued to be active. During 2001 the Cancer Health Initiative completed its fifth year of providing services in the community. Through with the use of clinics, health fairs, schools and churches, screenings were made available to residents of Richland, Lexington, Pickens and Fairfield counties. A special program for prostate cancer, Real Men…Checkin’ It Out, was created to promote prostate cancer awareness. The Trumpeter anti-tobacco use campaign provided smoking prevention programs to more than 4,000 sixth grade students. And our BuddyCall 19 feature continues to advocate annual mammography and monthly breast self examination

Basic and advanced oncology courses based on the Oncology Nursing Society requirements were offered throughout the year to nursing and professional staff as part of our professional staff educational process. Weekly staff development conferences were organized and conducted to fulfill continuing education requirements.

The Research division of the SCCC has been reorganized. The research is now overseen by a group of senior researchers who meet monthly. The principal focus of our research will continue to be on cancers that are major concerns for the citizens of South Carolina. These include but are not limited to breast, colon, prostate and cervical cancer. Separate research focus groups have been developed that are disease specific. These groups will attempt to develop new research projects that are clinically relevant to the population we serve.

Clinical research has grown dramatically in the last 2 years due in large part to the efforts of Dr. Fowler who began the CRISP program [Clinical Research Infrastructure Support Program] and Drs. Smith and Christiansen from South Carolina Oncology Associates who have worked to bring many new drug trials to our community. We have 6-8 percent of our patients participating in some clinical trial and this is several multiples of the U.S. average for adult oncology patients.

Patient care continues to be one of our great strengths. Our nursing units are consistently higher than the 90th percentile for patient satisfaction, despite the fact that they have been understaffed for much of the year. We have developed several programs to improve the quality of care for our patients. We gave you an update on the South Carolina Comprehensive Breast Center (SCCBC) last year and it continues to grow and improve the quality of care for our breast cancer patients. We have developed a similar program for prostate cancer patients that will be opened in September 2002. The South Carolina Comprehensive Prostate Center (SCCPC) will attempt to achieve the same improvement in quality of care that has been seen in the SCCBC. A comprehensive colon cancer will begin development in 2003.

The financial needs for the SCCC are being met by USC and Palmetto Health but the budgets are quite tight because of the state’s budget shortfall. We did have a record year for fundraising in 2001 and hope to exceed that in 2002.

The SCCC has received full participation from the researchers at the Veterans Hospital and they have become active in leadership positions within the SCCC. We have expanded clinical research protocols throughout the Palmetto Health hospital system. We are discussing ways to enhance cooperation with research projects developed by the Medical University of South Carolina.

In summary, we have begun to expand our research team, grow our research base within Columbia, develop new clinical programs, become more involved in educational activities and create new core laboratories within the South Carolina Cancer Center. The year 2001 was a good year but 2002 should prove to be a great year.

Publications

JOURNAL ARTICLES

Berger, Sondra, PhD

Phan, J., Koli, S., Minor, W., Dunlap, R.B., Berger, S.H., and Lebioda, L. Human Thymidylate Synthase Complexed with dUMP and Tomudex, an Antifolate Drug, is in the Closed Conformation. Biochemistry 40:1897-1902 (2001).

Phan, J., Steadman, D.J., Koli, S., Ding, W.C., Minor, W., Dunlap, R.B., Berger, S.H., and Lebioda, L. Structure of Human Thymidylate Synthase Suggests Approaches for Noncompetitive Inhibition. J. Biol. Chem. 276:14170-14177 (2001).

Yousef, A-M, Davis, R.A., Sticca, R.P., and Berger, S.H. Structural Analysis of cDNA Encoding Thymidylate Synthase in Hepatic Metastases of Human Colorectal Tumors. Int. J. Colorectal Dis. 16:318-325 (2001).

Bostick, Roberd M., MD, MPH

Bigler J, Whitton J, Lampe J.W., Fosdick L, Bostick R.M., Potter JD. CYP2C9 and UGT1A6 genotypes modulate the protective effect of aspirin on colon adenoma risk. Cancer Res 2001; 61:3566-3569.

Ulrich C.M., Bigler J, Whitton J.A., Bostick R.M., Fosdick L, Potter J.D. Epoxide hydrolase Tyr113His polymorphism is associated with elevated risk of colorectal polyps in the presence of smoking and high meat intake. Cancer Epidemiol Biomarker Prev 2001; 10:875-882.

Kim H.S., Newcomb P.A., Ulrich C.M., Keener C.L., Bigler J, Farin F.M., Bostick R.M., Potter J.D. Vitamin D receptor polymorphism and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calcium. Cancer Epidemiol Biomarker Prev 2001; 10:869-874.

Butler, William, MD

Ethnic Differences in Breast Cancer Characteristics. Butler W.M., Cunningham J. Breast Cancer On-Line Volume 4. 2001, May URL:HTTP www.bco.org2001.

Coker, Ann L., PhD

Ackerman, G.S., W.H. Tolleson, K.L. Brown, L.L. Zyzak, E. Mourateva, T.S.W. Engin, A. Basaraba, A.L. Coker, K.E. Creek, and L. Pirisi, Human papillomavirus type 16 E6 and E7 cooperate to increase epidermal growth factor receptor (EGFR) mRNA levels, overcoming mechanisms by which excessive EGFR signaling shortens the life span of normal human keratinocytes, Cancer Research, 61, 3837-3843, 9/30/2001, 2001.

Coker A.L., B.O. Pope, P.H. Smith, M. Sanderson, and J.R. Hussey, Assessment of Clinical Partner Violence Screening Tools, Journal of the American Medical Women's Association, 56, 19-23, 2001.

Coker A.L., L. Sanders, T. Gerasimova, and L. Pirisi, Hormonal and Barrier Methods of Contraception, Oncogenic HPVs and Cervical SIL Development, Journal of Women's Health and Gender-Based Medicine, 10(5), 441-449, 2001.

Coker A.L., T. Gerasimova, M.R. King, K.L. Jackson, and L. Pirisi, High Risk HPVs and Risk of Cervical Neoplasia: A Nested Case-Control Study, Experimental and Molecular Pathology, 70, 90-95, 2001.

Coker A.L., R.B. Russell, S.M. Bond, L. Pirisi, Y. Liu, M. Mane, N. Kokorina, T. Gerasimova, and P.L. Hermonat, Adeno-Associated Virus is Associated with a Lower Risk of High Grade Cervical Neoplasia, Experimental and Molecular Pathology, 70, 83-89, 2001.

Richter D.L., M.J. Harris, A.L. Coker, and J. Fraser, Limiting the Spread of HIV/AIDS in Sierra Leone: Opportunities for Intervention, Journal of the Association of Nurses in AIDS Care, 12(5), 25-31, 2001.

Creek, Kim, PhD

Akerman,G.S., Tolleson, W.H., Brown, K.L., Zyzak, L.L., Mourateva, E., Engin, T.S.W., Basaraba, A., Coker, A.L., Creek, K.E. and Pirisi, L.: Human papillomavirus type 16 E6 and E7 cooperate to increase epidermal growth factor receptor (EGFR) mRNA levels, overcoming mechanisms by which excessive EGFR signaling shortens the life span of normal human keratinocytes. Cancer Res. 61: 3837-3843, 2001

Walters, J.J., Muhammad, W., Fox, K.F., Fox, A., Xie, D., Creek, K.E., and Pirisi, L.: Genotyping single nucleotide polymorphisms using intact polymerase chain reaction products by electrospray quadrupole mass spectrometry. Rapid Commun. Mass Spectrom. 15: 1752-1759, 2001.

Cunningham, Joan, PhD

Kushi L.H., J. Cunningham, J.R. Hebert, R. Lerman, E.V. Bandera, and J. Teas, The Macrobiotic Diet in Cancer, J Nutr, 131, s3056-3064, 2001.

Newman L.A., A.A. Sahin, J.E. Cunningham, M.L. Bondy, N.Q. Mirza, G.S. Vlastos, G.J. Whitman, H. Brown, T.A. Buchholz, M.H. Lee, and S.E. Singletary, A Case-Control Study of Unilateral and Bilateral Breast Carcinoma Patients, Cancer, 91, 1845-1853, 2001.

Ethnic Differences in Breast Cancer Characteristics. Butler W.M., Cunningham J. Breast Cancer On-Line Volume 4. 2001, May URL:HTTP www.bco.org2001.

Hebert, James, ScD

Fowke J.H., C. Longcope, and J.R. Hebert, Macronutrient Intake and Estrogen Metabolism in Healthy Postmenopausal Women, Breast Cancer Res Treat, 65, 1-10, 2001.

Fowke J.H., J.W. Fahey, K.K. Stephenson, and J.R. Hebert, Using Isothiocyanate Excretion as a Biological Marker of Brassica Vegetable Consumption in Epidemiological Studies: Evaluating the Sources of Variability, Pub Health Nutr, 4, 837-846, 2001.

Hebert J.R., C.B. Ebbeling, T.G. Hurley, Y. Ma, L. Clemow, B.C. Olendzki, N. Saal and J.K. Ockene, Change in Women's Diet and Body Mass Following Intensive Intervention in Early-Stage Breast Cancer, J Am Diet Assoc, 101, 421-431, 2001. Hebert J.R., K.E. Peterson, T.G. Hurley, A.M. Stoddard, N. Cohen, A.E. Field, and G. Sorensen, The Effect of Social Desirability Train on Self-Reported Dietary Measures Among Multi-Ethnic Female Health Center Employees, Ann Epidemiol, 11, 417-427, 2001.

Kushi L.H., J. Cunningham, J.R. Hebert, R. Lerman, E.V. Bandera, and J. Teas, The Macrobiotic Diet in Cancer, J Nutr, 131, s3056-3064, 2001.

Matthews C.E., J.R. Hebert, E.J. Stanek III, P.S. Freedson, P.A. Merriam, C.B. Ebbeling, and I.S. Ockene, Sources of Variance in Daily Physical Activity Levels in the Seasonal Variation of Blood Cholesterol Study, Am J Epidemiol, 153, 987-995, 2001.

Matthews C.E., X.O. Shu, F. Jin, Q. Dai, J.R. Hebert, Z.X. Ruan, Y.T. Gao, and W.I. Zheng, Lifetime Physical Activity and Breast Cancer Risk in the Shanghai Breast Cancer Study, Br J Cancer, 84, 994-1001, 2001.

Rosal M.C., J.K. Ockene, Y. Ma, J.R. Hebert, P.A. Merriam, C.E. Matthews, and I.S. Ockene, Behavioral Risk Factors Among Members of a Health Maintenance Organization, Prev Med, 33, 586-594, 2001.

Shrubsole M.J., F. Jin, Q. Dai, X. Shu X.O., J.D. Potter, J.R. Hebert, Yt. Gao, and W. Zheng, Dietary Folate Intake and Breast Cancer Risk: Results from the Shanghai Breast Cancer Study, Cancer Res, 61, 7136-7141, 2001.

Wiecha J.M., A.K. Fink, J. Wiecha J., and J.R. Hebert, Differences in Dietary Patterns of Vietnamese, Caucasian, African-American, and Hispanic Adolescents in Worcester, MA., Differences in Dietary Patterns of Vietnamese, 101, 248-251, 2001.

Rosal M.C., C.B. Ebbeling, I. Lofgren, J.K. Ockene, I.S. Ockene, and J.R. Hebert, Facilitating Dietary Change: The Patient-Centered Counseling Model, J Am Dietet Assoc, 101, 332-341, 2001.

Rosal M.C., J.K. Ockene, Y. Ma, J.R. Hebert, P.A. Merriam, C.E. Matthews, and I.S. Ockene, Behavioral Risk Factors Among Members of a Health Maintenance Organization, Prev Med, 33, 586-594, 2001.

Saxe G.A., J.R. Hebert, J. Kabat-Zinn, J.F. Carmody, P.H. Rosenzweig, D. Jarzobski, G.W. Reed, R.D. Blute, Can Diet, In Conjunction with Stress Reduction, Affect the Rate of Increase in Prostate-Specific Antigen After Biochemical Recurrence of Prostate Cancer?, J Urol, 166, 2202-2207, 2001.

Hrushesky, William, PhD

Retsky M, Demicheli R, Hrushesky, W. Premenopausal Status Accelerates Relapse. BREA 65 (3), 217-224, February/March 2001.

Bjarnason G, Jordan R, Wood P.A., Li Qi, Lincoln D, Sothen R, Hrushesky W.J.M., Yaacov Ben-David. Circadian Expression of Clock Genes in Human Oral Mucosa and Skin; Association with Specific Cell-Cycle Phases. American Journal of Pathology, Vol 158 No 5, May 2001.

Lamb, Larry, PhD

Lowdell M.W., Lamb L.S., Hoyle C., Velardi, A, Prentice, H.G. Non-MHC restricted cytotoxic cells @ their roles in the control and treatment of leukemias. Br. J. Haem. 114: 11-24 (2001).

Szamania S., Galloway A., Bruorton M., Musk P., Aubert G., Arthur A., Pyle H., Hensel N., Lamb L., Dodi, T., Madrigal, A., Barrett, J., Henslee-Downey, J., VanRhee, F. Isolation and expansion of cytomegalovirus-specific cytotoxic T lymphocytes to clinical scale from a single blood draw using dendritic cells and HLA-tetramers. Blood 98: 505-512 (2001).

Musk, P., Szamania, S., Galloway, A., Johnson, K., Scott, A., Ta, N., Guttman, S., Bruorton, M., Garcia, V., Gatlin, J., Lamb, L., Chiang, K.Y., Spencer, T., Henslee-Downey, J., VanRhee, F. EBV-specific cytotoxic T cells for prevention of EBV-induced lymphoma in haplo-identical allogeneic stem cell transplantation. J. Immunotherapy 24: 312-322 (2001).

Lamb, L.S., Musk P., Ye Z., VanRhee F., Geier S.S., Tong J.J., King K.M., Henslee-Downey, P.J. Human g d+ T lymphocytes have in vitro graft versus leukemia activity in the absence of an allogeneic response. Bone Marrow Transplantation 27: 601-606, (2001).

Matthews, Chuck, PhD

Rosal M.C., J.K. Ockene, Y. Ma, J.R. Hebert, P.A. Merriam, C.E. Matthews, and I.S. Ockene, Behavioral Risk Factors Among Members of a Health Maintenance Organization, Prev Med, 33, 586-594, 2001.

Murdaugh, Carolyn, PhD

Phillips, K.D., Sowell, R.L., Rush, C.J., & Murdaugh, C.L., Correlates of Physical Health Among HIV-Infected Women at High Risk for Pregnancy in the Southeastern United States, On-line Journal of the Southern Nursing Research Society, 3, 2, 1-25, 2001.

Pirisi-Creek, Lucia, PhD

Walters J.J., Muhammad W., Fox K.F., Fox A., Xie D., Creek K.E., Pirisi L., Genotyping single nucleotide polymorphisms using intact polymerase chain reaction products by electrospray quadrupole mass spectrometry. Rapid Commun Mass Spectrom. 15:1752-1759, 2001.

Coker A.L., Sanders L.C., Bond S.M., Gerasimova T., Pirisi L., Hormonal and barrier methods of contraception, oncogenic human papillomaviruses, and cervical squamous intraepithelial lesion development. J Womens Health Gend Based Med. 10:441-449, 2001.

Akerman G.S., Tolleson W.H., Brown K.L., Zyzak L.L., Mourateva E., Engin T.S., Basaraba A., Coker AL., Creek K.E., Pirisi L., Human papillomavirus type 16 E6 and E7 cooperate to increase epidermal growth factor receptor (EGFR) mRNA levels, overcoming mechanisms by which excessive EGFR signaling shortens the life span of normal human keratinocytes. Cancer Res. 61:3837-3843, 2001.

Coker A.L., Gerasimova T., King M.R., Jackson K.L., Pirisi L., High-risk HPVs and risk of cervical neoplasia: a nested case-control study. Exp Mol Pathol. 70: 90-95, 2001.

Coker A.L., Russell R.B., Bond S.M., Pirisi L., Liu Y., Mane M., Kokorina N., Gerasimova T, Hermonat P.L., Adeno-associated virus is associated with a lower risk of high-grade cervical neoplasia. Exp Mol Pathol. 70:83-89, 2001.

Teas, Jane, PhD

Hebert J.R., Gupta P.C., Bhonsle R.B., Mehta H., Zheng W., Sanderson M., Teas J., Nutrient exposures and oral precancerous lesions in Srikakulam District, Andhra Pradesh, India. Public Health Nutr 2001; (In Press):00-000.

Dai Q., Shu X-O., Jin F., Potter J.D., Kushi L.H., Teas J., Gao Y-T, Zheng W., Population-based case-control study of soyfood intake and breast cancer risk in Shanghai. British Journal of Cancer 85(3), 372-378. 2001.

Kushi L.H., Cunningham, Hebert J.R., Lerman R.H., Bandera E.V., Teas J., The Macrobiotic Diet in Cancer. J. Nutr. 131: 3056S-3064S, 2001.

Wargovich, Michael, PhD

Wargovich M.J., Colon cancer chemoprevention with ginseng and other botanicals. Journal Korean Med Science, 2001 Dec., 16 Supplement: S81-6.

Wargovich M.J., Woods C., Hollis D.M., Zander M.E., Herbals, cancer prevention and health. J Nutr 131; 3034S-3036S, 2001.

Wargovich M.J., Herbals and cancer. Adv Exp Biol Med 492: 195-202, 2001.

Xie, Dawen, PhD

Zheng W., Xie D., Cerhan J.R., Sellers T.A., Wen W., Folsom A.R., Sulfotransferase 1A1 polymorphism, endogenous estrogen exposure, well-done meat intake, and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2001 Feb;10(2):89-94.

Zheng, W., Kataoka, N., Xie, D., Young, S. R. (2001). RESPONSE: Re: Population-Based, Case-Control Study of HER2 Genetic Polymorphism and Breast Cancer Risk.
J Natl Cancer Inst 93: 558-559

Zhao M, Xie D et al. GSTP1 Polymorphism, Meat Doneness Levels, and Cigarette Smoking and the Risk of Breast Cancer among Post-menopausal IOWA Women. Cancer Epidemiol Biomarkers Prev. 2001, in print.

BOOK CHAPTERS

Bostick, Roberd M., MD, MPH

Bostick R.M. Diet and nutrition in the etiology and primary prevention of colon cancer. In: Preventive Nutrition: The Comprehensive Guide for Health Professionals. 2nd Ed. Bendich A, Deckelbaum RJ, eds. Totowa, NJ: Humana Press, Inc., 2001;47-96.

Hebert, James, ScD

Ma Y., Hebert J.R., Ebbling C.B., Ockene I.S., International aspects of coronary heart disease: epidemiology, Cardiovascular Medicine: Practice and Management, Becker R.C., Alpert J.S., eds., 3-20, Arnold, London, 2001.

Matthews, Chuck, PhD

Ainsworth B.A., Matthews C.E., Physical Activity Epidemiology Research, In: Research Methods in Physical Activity, 4th edition, J.R. Thomas & J.K. Nelson Eds. Human Kinetics, Champaign, IL, 2001.

Wargovich, Michael, PhD

Hollis D.M., Wargovich M.J., Phytochemicals as modulators of cancer risk. In: Biologically active phytochemicals in foods. Pffannhauser W., Fenwick G.R., Khokar S. (eds)., Royal Society of Chemistry, London, pp 8-14, 2001.

BOOKS

Heiney, Sue, PhD

Cancer in the Family: Helping Children Cope with a Parent's Illness. authored by Heiney, S., Herman, J., Bruss, K. & Fincannon, J., published by American Cancer Society, 2001.

ABSTRACTS (PROCEEDINGS)

Bostick, Roberd M., MD, MPH

Bostick R.M., Boyapati S., McGlynn K., Modification of the calcium-incident sporadic colorectal adenoma association by vitamin D receptor genotype and NSAID use. Program and Abstracts, 25th Annual Meeting of the American Society of Preventive Oncology 2001.

Shi J-R, Valtorta M., Xie D., Bostick R.M., Predicting risk of prostate cancer with Bayesian Networks. Program and Abstracts, 25th Annual Meeting of the American Society of Preventive Oncology 2001.

Boyapati S.M., Bostick R.M., McGlynn K.A., Vitamin D intake, vitamin D receptor Bsm I polymorphisms, and risk for incident sporadic colorectal adenoma. Proc AACR 2001; 42:33.

Xie D., Deng Z., Lewis R.C., Shi J-R, Bostick R.M. CYP1A2 genetic polymorphisms and prostate cancer risk. Proc AACR 2001;42:345.

Lewis R.C., Xie D., Deng Z., Shi J-R, Bostick R.M., Polymorphisms of the cyclin D1 gene, CCND1, and risk for incident sporadic colorectal adenomas. Proc AACR 2001; 42:498.

Bigler J., Whitton J., Lampe J.W., Fosdick L., Bostick R.M., Potter J.D., CYP2C9 and UGT1A6 genotypes modulate the protective effect of NSAIDs on colon adenoma risk. Proc AACR 2001; 42:409.

Van Gils C., Bostick R., Stern M., Taylor J., Polymorphisms in DNA repair gene XRCC1, diet and prostate cancer risk. Proc AACR 2001; 42:599.

Cunningham J.E., Xie D., Hurley T.G., Bostick R.M., An insertion in the upstream regulatory sequence of CYP2E1 and risk of colon adenoma. Proc AACR 2001; 42:664.

Shi J-R, Bostick R.M., Xie D., Toshiro K., Staging prostate cancer using backpropagation neural networks. Proc AACR 2001; 42:885.

Cunningham, Joan, PhD

Cunningam J.E., D. Xie, T. Hurley and R. Bostick, An Insertion in the Upstream Regulatory Sequence of CYP2E1 and Risk of Colon Adenoma, Proc. AACR 93rd Annual Meeting, a3575, March, 2001.

Cunningham J.E., A. Cousins, J. Teas, and L. Kushi, Macrobiotics for Health, Healing and Cancer Prevention: Progress Report., Journal of Nutrition, 131, Washington, D.C., July 16-17, 2001.

Hrushesky, William, PhD

Hrushesky W., Sothern R., Rietveld W., Boon, M., Rhythmic Annual Changes in Cancer Biology Affect Epidemiologic Meaning, the Efficiency of Prevention, Screening and Treatment Strategies; In: 19th Annual VA Health Services Research and Development Services, Washington, DC; Feb 14-16, 2001.

Lamb, Larry, PhD

Lamb L,S., Meeh P.F., Paoli, M., King, K.M., Haley N.R., Determination of CD34 absolute count from apheresis specimens shipped overnight from a single reference laboratory: a comparison of single and dual platform methods. Blood 98: 181a (2001)

Musk P, King KM, Lamb, LS. A specific gamma/delta T cell population targets acute lymphoblastic leukemia. The FASEB Journal; 2001: A666.

Pirisi-Creek, Lucia, PhD

Baldwin, A., Canhoto, A.J., Pirisi, L., and Creek, K.E.: NF-1 Binding sites mediate transforming growth factor-b inhibition of the human papillomavirus type 16 early promoter. Proc. Amer. Assoc. Cancer Res. 42: 117, 2001.

Pirisi, L., Borger, D.R., Baldwin, A., Asbury, M.K., Canhoto, A.J., Mourateva, E., Akerman, G.S. and Creek, K.E. Transforming Growth Factor-beta and HPV16 E7: A Balance of Opposite Influences. HPV2001: 19th International Papillomavirus Conference, Florianopolis, Brazil, September 1-7, 2001.

Coker, A.L., Bond, S., Madeline, M., King, M., Gerasimova, T. and Pirisi, L., Stressful Life Events and Risk of HR-HPV Persistence. HPV2001: 19th International Papillomavirus Conference, Florianopolis, Brazil, September 1-7, 2001.

Teas, Jane, PhD

Cunningham J.E., A. Cousins, J. Teas, and L. Kushi, Macrobiotics for Health, Healing and Cancer Prevention: Progress Report., Journal of Nutrition, 131, Washington, D.C., July 16-17, 2001.

Teas J., S. Pino, J. Cunningham, T. Hurley, A. Critchley, and L. Braverman, Iodine in Dietary Seaweeds: Range of Values and Possible Concerns, Presented at the International Seaweed Symposium, South Africa, January, 2001.

Wargovich, Michael, PhD

Hollis D.M., Muga S., Wargovich M.J., Structure-activity relationships of garlic compounds and the inhibition of hepatic CYP2E1. Proc Amer Assoc Cancer Res 42: 4653, 2001.

Wargovich M.J., Woods C., Liao J., Hollis D.M., Marquart L., Good C. Calcium-fortified whole grain diet inhibits aberrant crypt foci in the rat colon. Proc Amer Assoc Cancer Res 42: 949, 2001.